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Products Details
Product Description
– Compounds 6b and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6k was effective on HCA XII. Compounds 6b, 14g and 6k can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.
Web ID
– HY-147663
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H12N2O4S
References
– [1]Swain B,et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.
CAS Number
– 2451479-86-8
Molecular Weight
– 352.36
SMILES
– N#CC1=CC=C(C=C1)/C=C/C(NC2=CC3=C(OS(=O)(C=C3)=O)C=C2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA XII
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
