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Halofuginone hydrobromide
Price range: 50 CAD through 1,594 CAD
Products Details
Product Description
– Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Web ID
– T3524
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H17BrClN3O3.HBr
Citations
– 1. Kaduk J A, Gates-Rector S, Blanton T N. Crystal structure of halofuginone hydrobromide, C16H18BrClN3O3Br. Powder Diffraction. 2022: 1-8.
2. Zhu J, Wei J, Lin Y, et al.Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.BMC Complementary Medicine and Therapies.2024, 24(1): 1-12.
References
– Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
CAS Number
– 64924-67-0
Molecular Weight
– C16H17BrClN3O3.HBr
Compound Purity
– 0.985
SMILES
– Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Target
– Others
Pathway
– Metabolism|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||Microbiology/Virology|||Stem Cells
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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