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Product Description
– GZD856 formic is a potent and orally active PDGFRα/β inhibitor, with IC50s of 68.6 and 136.6 nM, respectively. GZD856 formic is also a Bcr-AblT315I inhibitor, with IC50s of 19.9 and 15.4 nM for native Bcr-Abl and the T315I mutant. GZD856 formic has antitumor activity[1][2].
Web ID
– HY-101489
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H27F3N6O
References
– [1]Zhang Z, et al. GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo. Cancer Lett. 2016 May 28;375(1):172-178.|[2]Lu X, et al. Synthesis and identification of GZD856 as an orally bioavailable Bcr-AblT315I inhibitor overcoming acquired imatinib resistance. J Enzyme Inhib Med Chem. 2017 Dec;32(1):331-336.
CAS Number
– 1257628-64-0
Molecular Weight
– 532.56
SMILES
– O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN5C(N=C4)=CC=N5)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Apoptosis;Bcr-Abl;PDGFR
Isoform
– Bcr-Abl;PDGFRα;PDGFRβ
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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