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GW3965 (hydrochloride)
$72 – $804
Products Details
Product Description
– GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
Web ID
– HY-10627A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C33H32Cl2F3NO3
Citations
– bioRxiv. 2023 Mar 10.|Radboud University Nijmegen. 2021 Mar.|Viruses. 2022, 14(3), 514.|Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. |Bioconjug Chem. 2015 Nov 18;26(11):2216-22. |Cancer Lett. 2023 May 5;216208.|Cell Death Differ. 2020 Aug;27(8):2433-2450. |J Am Heart Assoc. 2021 May 8;e018455.|J Ethnopharmacol. 2023 May 24;315:116684.|Sci Adv. 15 Jul 2022.|Theranostics. 2020 Jul 11;10(19):8834-8850.
References
– [1]Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6.|[2]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.|[3]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.|[4]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.
CAS Number
– 405911-17-3
Molecular Weight
– 618.51
Compound Purity
– 99.92
SMILES
– ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– LXR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
