Download Files:
GW 4064
$60 – $1,020
Products Details
Product Description
– GW 4064 is a potent FXR agonist with an EC50 of 65 nM.
Web ID
– HY-50108
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H22Cl3NO4
References
– [1]Akwabi-Ameyaw A, et al.Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett, 2008, 18(15), 4339-4343.|[2]Ma Y, et al. Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and resistance. Pharm Res. 2013 May;30(5):1447-57.|[3]Liu Y, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest. 2003 Dec;112(11):1678-87.
CAS Number
– 278779-30-9
Molecular Weight
– 542.84
Compound Purity
– 98.92
SMILES
– O=C(C1=CC=CC(/C=C/C2=CC=C(C=C2Cl)OCC3=C(ON=C3C4=C(Cl)C=CC=C4Cl)C(C)C)=C1)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cancer
Solubility
– DMF : 100 mg/mL (ultrasonic)|DMSO : 100 mg/mL (ultrasonic)
Target
– Autophagy;FXR
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
