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GSK3735967
$300 – $2,400
Products Details
Product Description
– GSK3735967 is an selective, reversible, non-nucleoside inhibitor of DNMT1 with an IC50 value of 40 nM. GSK3735967 contains a planar dicyanopyridine core that can specifically embed DNMT1 bound hemimethylated CpG dinucleotides. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3[1][2].
Web ID
– HY-150249
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Molecular Formula
– C25H31N7OS
References
– [1]Horton JR, et al. Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure. 2022 Jun 2;30(6):793-802.e5.|[2]Horton J, et al. Structural Studies of DNMT1-DNA Complexes with a Reversible Series of Dicyanopyridine Containing Selective, Non-Nucleoside Inhibitors[J]. Foundations of Crystallography, 2022, 78: a246.
CAS Number
– 2170136-86-2
Molecular Weight
– 477.62
Compound Purity
– 99.71
SMILES
– N#CC1=C(SCC2=CC=C(CNC(CN)=O)C=C2)N=C(N3CCN(CCC3)C)C(C#N)=C1CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 70°C)
Target
– DNA Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
