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GSK126
Price range: 59 CAD through 766 CAD
Products Details
Product Description
– GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).
Web ID
– T2079
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C31H38N6O2
Citations
– 1. Wu D, Yan Y, Wei T, et al. An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors. Cell Reports. 2021, 34(7): 108744.
2. Zhang Q, Chen X, Cao J, et al.Discovery of a Novel Covalent EZH2 Inhibitor Based on Tazemetostat Scaffold for the Treatment of Ovarian Cancer.Journal of Medicinal Chemistry.2023
3. Xu C, Zhao W, Peng L, et al.PRDM14 extinction enables the initiation of trophoblast stem cell formation.Cellular and Molecular Life Sciences.2024, 81(1): 208.
4. Treekitkarnmongkol W, Shah V, Kai K, et al.Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer.British Journal of Cancer.2024: 1-13.
References
– Ott HM, et al. A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation. Mol Cancer Ther. 2014 Dec;13(12):3062-73.
CAS Number
– 1346574-57-9
Molecular Weight
– C31H38N6O2
Compound Purity
– 0.9943
SMILES
– CC[C@H](C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Target
– Others
Pathway
– Chromatin/Epigenetic
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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