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GSK-3484862
$55 – $650
Products Details
Product Description
– GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity[1][2].
Web ID
– HY-135146
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H19N5OS
References
– [1]Nathalia Azevedo Portilho, et al. The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells.|[2]Keystone Symposia 2019 – Epigenetics and Human Disease
CAS Number
– 2170136-65-7
Molecular Weight
– 365.45
Compound Purity
– 99.62
SMILES
– O=C(N)[C@H](SC1=NC(N(C)C)=C(C#N)C(CC)=C1C#N)C2=CC=CC=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 20.83 mg/mL (ultrasonic)
Target
– DNA Methyltransferase
Isoform
– DNMT1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
