GSK 3 Inhibitor IX
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GSK 3 Inhibitor IX

SKU T1917-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 59 CAD through 2,192 CAD

Products Details

Product Description

– GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.

Web ID

– T1917

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H10BrN3O2

Citations

– 1. Wen J, Li X, Zhao Q X, et al. Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells. Emerging microbes & infections. 2022, 11(1): 391-405 2. Wen J, Li X, Zhao Q X, et al. Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells: Suppression of GSK3 reactivates HIV-1 from latency. Emerging Microbes & Infections. 2022 (just-accepted): 1-36.

References

– Meijer L, et al. Chem Biol, 2003, 10(12), 1255-1266.

CAS Number

– 667463-62-9

Molecular Weight

– C16H10BrN3O2

Compound Purity

– 0.9972

SMILES

– ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Br)ccc12

Target

– Antifection|||HBV

Pathway

– Stem Cells|||Apoptosis|||Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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