GSK-25
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GSK-25

SKU T4488-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 62 CAD through 765 CAD

Products Details

Product Description

– GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).

Web ID

– T4488

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H16Cl2F2N6O

Citations

– 1. Yuan Y, Xu J, Jiang L, et al. Discovery, Optimization, and Structure–Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma. Journal of Medicinal Chemistry. 2021

References

– Sehon CA, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases [J]. J Med Chem. 2008 Nov 13;51(21):6631-4.

CAS Number

– 874119-56-9

Molecular Weight

– C24H16Cl2F2N6O

Compound Purity

– 0.9859

SMILES

– CC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F

Pathway

– PI3K/Akt/mTOR signaling|||MAPK|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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