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Products Details
Product Description
– GRL018-21 is a potent and highly selective G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 value of 10 nM[1].
Web ID
– HY-149720
Shipping
– Room temperature
Molecular Formula
– C30H25FN4O5
References
– [1]Chen Y, et al. Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes[J]. European Journal of Medicinal Chemistry, 2023: 115931.
Molecular Weight
– 540.54
SMILES
– FC1=CC=C([C@@H](C)NC(C2=CC=C(NC(/C3=CC4=C(C)C(NC(C(C5=CC=CO5)=O)=O)=C(C)N4)=O)C3=C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– G Protein-coupled Receptor Kinase (GRK)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
