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Products Details
Product Description
– GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC50 value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis[1].
Web ID
– HY-156286
Shipping
– Room temperature
Molecular Formula
– C25H23ClN4O4
References
– [1]Zhu JM, et al. Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer. Eur J Med Chem. 2023 Sep 28;261:115829.
Molecular Weight
– 478.93
SMILES
– O=C(NCC1CCN(CC1)C(CCl)=O)C(C=C2C/3=O)=CC=C2NC3=C4C(C=CC=C5)=C5NC4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ferroptosis
Pathway
– Apoptosis
Product type
– Reference compound
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