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GPR84 antagonist 2
$480 – $4,000
Products Details
Product Description
– GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].
Web ID
– HY-145697
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H16Cl2NaO4PS2
References
– [1]Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65(5):3991-4006.
CAS Number
– 2244269-74-5
Molecular Weight
– 605.42
Compound Purity
– 99.53
SMILES
– O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)O[Na]
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– GPR84
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
