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Products Details
Product Description
– GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity[1].
Web ID
– HY-16984
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H27F2N5O3S
References
– [1]Burch JD, et al. Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo. J Med Chem. 2015 May 14;58(9):3806-16.
CAS Number
– 1705602-02-3
Molecular Weight
– 515.58
SMILES
– O=C(C1=NNC2=C1C[C@H](C3(F)F)[C@@]3(C)C2)NC4=CN([C@H](C5=CC=CC=C5)[C@@H]6S(CCCC6)(=O)=O)N=C4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Itk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
