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Products Details
Product Description
– Glucagon receptor antagonists-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM). Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM)[1].
Web ID
– HY-128781
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C30H29ClF3N3O3
References
– [1]Xu G, et al. Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126668.
CAS Number
– 2200274-63-9
Molecular Weight
– 572.02
SMILES
– O=C(NCCC(O)=O)C1=CC=C([C@@H](N2N=CC3=C2C=C(C)C(C4=CC=C(C(F)(F)F)C=C4Cl)=C3)CC(C)C)C=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– GCGR
Pathway
– GPCR/G Protein
Product type
– Reference compound
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