GLPG2451

$350$2,250

Products Details

Product Description

– GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].

Web ID

– HY-119936

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C16H16F3N3O5S

References

– [1]Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.

CAS Number

– 2055015-61-5

Molecular Weight

– 419.38

Compound Purity

– 99.68

SMILES

– O=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[C@@H](O)C)=O)C(N)=C2)=O

Clinical Information

– Phase 1

Research Area

– Inflammation/Immunology

Solubility

– DMSO : 250 mg/mL (ultrasonic)

Target

– Autophagy;CFTR

Pathway

– Autophagy;Membrane Transporter/Ion Channel

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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