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Products Details
Product Description
– GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1].
Web ID
– HY-101119
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H23BO4
References
– [1]Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368.
CAS Number
– 2077980-80-2
Molecular Weight
– 398.26
SMILES
– OC(/C=C/C(C=C1)=CC=C1/C(C2=CC=C(B(O)O)C=C2)=C(C3=CC=CC=C3)/CC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Estrogen Receptor/ERR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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