Glipizide-d11

$516$2,475

Products Details

Product Description

– Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].

Web ID

– HY-B0254S

Shipping

– Room temperature

Molecular Formula

– C21H16D11N5O4S

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]B J Zünkler, et al. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells. Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337(2):225-30.|[3]Glipizide. From Wikipedia

CAS Number

– 1189426-07-0

Molecular Weight

– 456.60

SMILES

– [2H]C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])NC(NS(=O)(C2=CC=C(C=C2)CCNC(C3=NC=C(C)N=C3)=O)=O)=O

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease

Solubility

– 10 mM in DMSO

Target

– Isotope-Labeled Compounds;Potassium Channel

Pathway

– Membrane Transporter/Ion Channel;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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