Gemcitabine hydrochloride
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Gemcitabine hydrochloride

SKU T6069-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 155 CAD

Products Details

Product Description

– Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

Web ID

– T6069

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C9H11F2N3O4·HCl

Citations

– 1. Huang C S, You X, Dai C, et al. Targeting Super-Enhancers via Nanoparticle-Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma. Advanced Science. 2020, 7(7): 1902926 2. Huang C S, You X, Dai C, et al. Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma. Advanced Science. 2020: 1902926. 3. Zhuang K R, Chen C F, Chan H Y, et al.Andrographolide suppresses the malignancy of pancreatic cancer via alleviating DNMT3B-dependent repression of tumor suppressor gene ZNF382.Phytomedicine.2024: 155860. 4. Zhu Y Q, Huang Y, Shi Y H, et al.Epigenetic Activation of the CMTM6‐IGF2BP1‐EP300 Positive Feedback Loop Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma.Advanced Science.2024: 2406714.

References

– Amrutkar M, et al. Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing. Cancers (Basel). 2020 Dec 3;12(12):3628.

CAS Number

– 122111-03-9

Molecular Weight

– C9H11F2N3O4·HCl

Compound Purity

– 0.9985

SMILES

– Cl.Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1

Pathway

– Apoptosis|||Cell Cycle/Checkpoint|||Autophagy|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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