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GDC-0575 (dihydrochloride)
$140 – $1,170
Products Details
Product Description
– GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
Web ID
– HY-112167A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H22BrCl2N5O
Citations
– bioRxiv. 2023 Feb 7.|Mol Cancer Res. 2020 Jan;18(1):91-104.|Nat Commun. 2020 Jan 8;11(1):123. |Neurotherapeutics. 2022 Mar;19(2):570-591.
References
– [1]Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8(1):1679.|[2]Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Jun 15;24(12):2901-2912.
CAS Number
– 1657014-42-0
Molecular Weight
– 451.19
Compound Purity
– 99.49
SMILES
– O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl.[H]Cl
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : 65 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Target
– Checkpoint Kinase (Chk)
Isoform
– Chk1
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
