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Products Details
Product Description
– GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
Web ID
– HY-111442
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C26H27NO6
References
– [1]Koehler K, et al. Thyroid receptor ligands. 6. A high affinity “direct antagonist” selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7.|[2]Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5′-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46.|[3]Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20.
CAS Number
– 447415-34-1
Molecular Weight
– 449.50
SMILES
– O=C(O)COC1=CC(C)=C(CC2=CC(C3=CC=C([N+]([O-])=O)C=C3)=C(O)C(C(C)C)=C2)C(C)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Thyroid Hormone Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
