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Ganciclovir
$64 – $128
Products Details
Product Description
– Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].
Web ID
– HY-13637
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C9H13N5O4
Citations
– Antiviral Res. 2021 Jun 28;105124.|Brain Behav Immun. 2019 Aug;80:394-405. |Cell. 2020 Nov 25;183(5):1402-1419.e18.|Cells. 2019 Dec 20;9(1):31.|Eur J Pharm Sci. 2019 Jan 15;127:29-37.|J Nanobiotechnology. 2022 Jul 20;20(1):340.|J Virol. 2017 Jan 18;91(3). pii: e02152-16.|Microchem J. 2021, 106587.|Pharmaceutics. 2023 Nov 27, 15(12), 2680.|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Sci Data. 2022 Oct 8;9(1):610.|Biochem Pharmacol. 2022 Jan 15;114917.|bioRxiv. 2023 Sep 20.|Research Square Print. 2023 Mar.
References
– [1]Boujemla I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016;132:111-115.|[2]Fletcher CV, et al. Evaluation of ganciclovir for cytomegalovirus disease. DICP. 1989 Jan;23(1):5-12.|[3]Matthews T, et al. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4.|[4]Duan J, Paris W, Kibler P, Bousquet C, Liuzzi M, Cordingley MG. Dose and duration-dependence of ganciclovir treatment against murine cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 1998;39(3):189-197.|[5]Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39(4):597-638.|[6]Maggs DJ, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403.
CAS Number
– 82410-32-0
Molecular Weight
– 255.23
Compound Purity
– 99.77
SMILES
– O=C1NC(N)=NC2=C1N=CN2COC(CO)CO
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : 60 mg/mL (ultrasonic)|H2O : 1.67 mg/mL (ultrasonic)
Target
– Antibiotic;CMV;HSV;Nucleoside Antimetabolite/Analog
Isoform
– HSV-1;HSV-2
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
