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Gabapentin
$30 – $90
Products Details
Product Description
– Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain[1][2][3].
Web ID
– HY-A0057
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C9H17NO2
Citations
– ACS Pharmacol Transl Sci. 2023 Mar 6.|Cell Rep. 2019 Dec 17;29(12):3847-3858.e5.|iScience. 2023 Jun 27.|J Nat Med. 2021 Sep 12.|J Pain. 2019 May;20(5):577-591. |Pharmacol Res Perspect. 2021 Oct;9(5):e00879.|Sci Total Environ. 2022 Jul 10;829:154437.|Eur J Drug Metab Pharmacokinet. 2022 Jun 22.
References
– [1]Fink K, et, al. Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun;130(4):900-6.|[2]Celikyurt IK, et, al. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1;492(2):124-8.|[3]Meymandi MS, et, al. Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. Eur J Anaesthesiol. 2008 Feb;25(2):129-34.
CAS Number
– 60142-96-3
Molecular Weight
– 171.24
Compound Purity
– 98.0
SMILES
– O=C(O)CC1(CN)CCCCC1
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– Calcium Channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
