Download Files:
Products Details
Product Description
– G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer[1].
Web ID
– HY-151263
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C36H49ClFN7O4
References
– [1]Jiang XC, et al. Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2022 Sep 2.
Molecular Weight
– 698.27
SMILES
– O=C(NCCCN(C)C)C1=CC=C(/C=C2CCN3C2=NC4=C(C=C(F)C(N5CCN(CCCCCCCC(NO)=O)CC5)=C4)C3=O)C=C1.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– G-quadruplex;HDAC
Isoform
– HDAC1;HDAC11;HDAC4;HDAC6;HDAC8
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
