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G-418 (disulfate)
$50 – $192
Products Details
Product Description
– G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells[1].
Web ID
– HY-17561
Storage Temperature
– 4°C (Powder, stored under nitrogen, away from moisture)
Shipping
– Room Temperature
Molecular Formula
– C20H44N4O18S2
Citations
– Am J Cancer Res. 2021 May 15;11(5):2062-2080.|Cancer Commun (Lond). 2022 Nov 9.|Cancer Res. 2023 Feb 6;CAN-22-3169.|Cell Death Differ. 2020 Jun;27(6):1981-1997.|Cell Death Dis. 2020 Jun 4;11(6):420.|Cell Death Dis. 2019 May 28;10(6):413.|Cell Rep. 2020 Oct 20;33(3):108287.|Cell Rep. 2021 Mar 30;34(13):108906.|Cell Rep. 2021 Sep 21;36(12):109739.|Cell Rep. 2022 Oct 25;41(4):111561.|Emerg Microbes Infect. 2023 Sep 19;2261556.|Hum Cell. 2022 Jul 6.|J Agric Food Chem. 2022 Apr 6;70(13):3989-3999.|J Biol Chem. 2023 Mar 17;104621.|J Cell Mol Med. 2023 Mar 13.|J Genet Genomics. 2021 Mar 30.|Med Oncol. 2021 Nov 10;39(1):10.|Mol Cell. 2023 Nov 20:S1097-2765(23)00914-0.|Nature. 2023 Jun;618(7966):862-870.|Oxid Med Cell Longev. 2022 Jan 28;2022:8168988.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2021 Nov.|Research Square Print. 2023 Feb 21.|Theranostics. 2022 Jan 1;12(3):1187-1203.|Transl Cancer Res. 2023 Jan 23; 12(1):150-162.|Acta Pharmacol Sin. 2023 May 16.|FASEB J. 2023 Nov;37(11):e23195.|Research Square Preprint. 2023 Jul 11.
References
– [1]Giordano-Santini R, et al. An antibiotic selection marker for nematode transgenesis. Nat Methods. 2010;7(9):721-723.|[2]Volarevic M, et al. A novel G418 conjugate results in targeted selection of genetically protected hepatocytes without bystander toxicity. Bioconjug Chem. 2007;18(6):1965-1971.|[3]Kwon KM, et al. Disialyl GD2 ganglioside suppresses ICAM-1-mediated invasiveness in human breast cancer MDA-MB231 cells. Int J Biol Sci. 2017;13(3):265-275. Published 2017 Feb 12.|[4]Davies J, et al. A new selective agent for eukaryotic cloning vectors. Am J Trop Med Hyg. 1980;29(5 Suppl):1089-1092.
CAS Number
– 108321-42-2
Molecular Weight
– 692.71
Compound Purity
– 98.26
SMILES
– O=S(O)(O)=O.O[C@@H]([C@@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)N)([H])O[C@]2([H])[C@H](O)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O.O=S(O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– H2O : 125 mg/mL (ultrasonic)
Target
– Antibiotic;Bacterial
Isoform
– Aminoglycoside
Pathway
– Anti-infection
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
