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Fosbretabulin (disodium)
$42 – $450
Products Details
Product Description
– Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3].
Web ID
– HY-17449
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H19Na2O8P
References
– [1]Shen CH, et, al. Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model. Br J Pharmacol. 2010 Aug;160(8):2008-27.|[2]Pettit GR, et, al. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J Med Chem. 2005 Jun 16;48(12):4087-99.|[3]Tozer GM, et, al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res. 1999 Apr 1;59(7):1626-34.
CAS Number
– 168555-66-6
Molecular Weight
– 440.29
Compound Purity
– 99.82
SMILES
– COC1=C(OC)C(OC)=CC(/C=CC2=CC=C(OC)C(OP(O[Na])(O[Na])=O)=C2)=C1
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMF : 1 mg/mL (ultrasonic)|DMSO : < 1 mg/mL|H2O : 4.5 mg/mL (ultrasonic;warming)
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
