Products Details

Product Description

– Fosaprepitant-d4 (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

Web ID

– HY-14407AS

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C37H52D4F7N6O16P

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Molecular Weight

– 1008.86

SMILES

– OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OC([2H])([2H])C2([2H])[2H])[C@@](C3=CC=C(C=C3)F)([H])N2CC4=NN(C(N4)=O)P(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC

Clinical Information

– No Development Reported

Research Area

– Neurological Disease; Endocrinology; Cancer

Solubility

– 10 mM in DMSO

Target

– Isotope-Labeled Compounds;Neurokinin Receptor

Pathway

– GPCR/G Protein;Neuronal Signaling;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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