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Products Details
Product Description
– Fosaprepitant-d4 (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].
Web ID
– HY-14407AS
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C37H52D4F7N6O16P
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 1008.86
SMILES
– OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OC([2H])([2H])C2([2H])[2H])[C@@](C3=CC=C(C=C3)F)([H])N2CC4=NN(C(N4)=O)P(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology; Cancer
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Neurokinin Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
