– Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide group. Serving as a building block in Solid Phase Peptide Synthesis (SPPS), it is utilized in the helping hand strategy for purifying highly insoluble peptides. The solubilizing residue is attached to the lysine side chain through click chemistry. The solubilization tag can be removed with a 1M solution of hydrazine or hydroxylamine.