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Products Details
Product Description
– Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis[1]. Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Web ID
– HY-151738
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H18N4O4
References
– [1]Fernández-Llamazares AI, et al. The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera. Org Lett. 2013 Sep 6;15(17):4572-5.|[2]Kruijtzer JA, et al. Peptoid-peptide hybrids as potent novel melanocortin receptor ligands. J Med Chem. 2005 Jun 30;48(13):4224-30.|[3]Kim JK, et al. Structural flexibility and the positive charges are the key factors in bacterial cell selectivity and membrane penetration of peptoid-substituted analog of Piscidin 1. Biochim Biophys Acta. 2010 Oct;1798(10):1913-25.
CAS Number
– 1935981-35-3
Molecular Weight
– 366.37
SMILES
– [N-]=[N+]=NCCN(CC(O)=O)C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– ADC Linker
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
