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Fluticasone
SKU
HY-B0603-Get quote
Category Reference compound
Tags Glucocorticoid Receptor;Smo, Immunology/Inflammation;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor, Infection; Endocrinology; Inflammation/Immunology
Products Details
Product Description
– Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].
Web ID
– HY-B0603
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C22H27F3O4S
References
– [1]Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13(1):90.|[2]Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107(20):9323-8. |[3]Ying Wang, et al. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front. Cell. Infect. Microbiol., 2020 Jun. |[4]Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26. 385(Suppl 1):S88.
CAS Number
– 90566-53-3
Molecular Weight
– 444.51
SMILES
– C[C@]([C@](O)1C(SCF)=O)(C[C@@H]2O)[C@](C[C@H]1C)([H])[C@@](C[C@@H]3F)([H])[C@]2([C@](C3=CC4=O)(C=C4)C)F
Clinical Information
– Launched
Research Area
– Infection; Endocrinology; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Glucocorticoid Receptor;Smo
Pathway
– Immunology/Inflammation;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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