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Flupentixol (dihydrochloride)
SKU
HY-15856B-10 mg
Category Reference compound
Tags Apoptosis;Dopamine Receptor;PI3K, Apoptosis;GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR, Cancer; Neurological Disease
$50 – $250
Products Details
Product Description
– Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].
Web ID
– HY-15856B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H27Cl2F3N2OS
References
– [1]Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.|[2]Chao Dong, et al. The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer. Int J Biol Sci. 2019 Jun 2;15(7):1523-1532.|[3]Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.
CAS Number
– 2413-38-9
Molecular Weight
– 507.44
Compound Purity
– 99.73
SMILES
– OCCN1CCN(CC/C=C2C3=C(SC4=C/2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl
Clinical Information
– Launched
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Apoptosis;Dopamine Receptor;PI3K
Isoform
– D1 Receptor;D2 Receptor;PI3Kα
Pathway
– Apoptosis;GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR
Product type
– Reference compound
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