Flupentixol (dihydrochloride)

$50$250

Products Details

Product Description

– Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].

Web ID

– HY-15856B

Storage Temperature

– 4°C (Powder, sealed storage, away from moisture and light)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C23H27Cl2F3N2OS

References

– [1]Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.|[2]Chao Dong, et al. The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer. Int J Biol Sci. 2019 Jun 2;15(7):1523-1532.|[3]Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.

CAS Number

– 2413-38-9

Molecular Weight

– 507.44

Compound Purity

– 99.73

SMILES

– OCCN1CCN(CC/C=C2C3=C(SC4=C/2C=CC=C4)C=CC(C(F)(F)F)=C3)CC1.[H]Cl.[H]Cl

Clinical Information

– Launched

Research Area

– Cancer; Neurological Disease

Solubility

– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

Target

– Apoptosis;Dopamine Receptor;PI3K

Isoform

– D1 Receptor;D2 Receptor;PI3Kα

Pathway

– Apoptosis;GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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