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Fingolimod
$61 – $825
Products Details
Product Description
– Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].
Web ID
– HY-11063
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C19H33NO2
Citations
– Am J Physiol Cell Physiol. 2023 Oct 2.|Commun Biol. 2021 Mar 25;4(1):399.|Front Endocrinol (Lausanne). 2018 Mar 22;9:120. |Front Pharmacol. 2018 Oct 31;9:1237. |Helicobacter. 2019 Oct;24(5):e12652.|J Gastroenterol Hepatol. 2018 Jan 15. |J Mol Cell Cardiol. 2021 Nov 10;S0022-2828(21)00210-8.|Mol Neurobiol. 2023 Oct 11.|Research Square Preprint. 2023 Sep 6.|Wound Repair Regen. 2023 May 2.|Breast Cancer Res. 2017 Aug 4;19(1):90. |Cancer Lett. 2018 Aug 16;436:75-86. |Cell Res. 2022 Feb 1.|Eur J Pharmacol. 2022 Sep 12;175271.|Haematologica. 2020 Mar;105(3):674-686.|Int Immunopharmacol. 2021 Apr 26;96:107511.|J Immunol Sci. March 31, 2022.|Life Sci. 2019 Jan 15;217:243-250.|Nat Commun. 2022 Jan 10;13(1):182.|Patent. US20210393524A1.|PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. |Reprod Biomed Online. 2023 Jul 22, 103304.|Research Square Preprint. 2023 Dec 1.|Theranostics. 2021 Jan 1;11(1):117-131.|Vet Microbiol. 2021, 109177.
References
– [1]Shirakabe K, et al. Modification of lymphocyte migration to Peyer’s patches by inhibition of sphingosine-1-phosphate lyase ameliorates murine colitis. J Gastroenterol Hepatol. 2018 Jan 15.|[2]Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586.|[3]Airas L, et al. In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. J Nucl Med. 2015 Feb;56(2):305-10.|[4]Szepanowski F, et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. J Neuroinflammation. 2016 Jun 10;13(1):143.
CAS Number
– 162359-55-9
Molecular Weight
– 307.47
Compound Purity
– 99.56
SMILES
– OCC(CCC1=CC=C(CCCCCCCC)C=C1)(N)CO
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 7.69 mg/mL (ultrasonic)
Target
– LPL Receptor;PAK
Isoform
– PAK1
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
