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FIN56
Price range: 56 CAD through 1,968 CAD
Products Details
Product Description
– FIN56, a specific inducer of ferroptosis, is identified by its IUPAC name [1,3,8-trihydroxy-6-methylanthracen-9(10H)-one].
Web ID
– T4066
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H31N3O5S2
Citations
– 1. Yan B, Ai Y, Sun Q, et al. Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1. Molecular Cell. 2020
2. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.
3. Bi G, Liang J, Bian Y, et al.Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer.Nature Communications.2024, 15(1): 2461.
4. Ru Y, Luo Y, Liu D, et al.Isorhamnetin alleviates ferroptosis-mediated colitis by activating the NRF2/HO-1 pathway and chelating iron.International Immunopharmacology.2024, 135: 112318.
5. Liao W, Zhang R, Chen G, et al.Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.Biomedicine & Pharmacotherapy.2024, 176: 116832.
6. In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
References
– Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.
CAS Number
– 1083162-61-1
Molecular Weight
– C25H31N3O5S2
Compound Purity
– 0.9978
SMILES
– ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1
Pathway
– Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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