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Products Details
Product Description
– FGFR1 inhibitor-8 (Compound 9) is a FGFR1 inhibitor (IC50s: 0.5 nM). FGFR1 inhibitor-8 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-8 has anticancer activity[1].
Web ID
– HY-149487
Shipping
– Room temperature
Molecular Formula
– C26H18ClNO5
References
– [1]Ronnakorn Leechaisit, et al. Discovery of Novel Naphthoquinone鈥揅halcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling. ACS Omega 2023.
Molecular Weight
– 459.88
SMILES
– O=C1C(Cl)=C(NC2=CC=C(C(/C=C/C3=CC=C(OC)C(O)=C3)=O)C=C2)C(C4=C1C=CC=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
