Fedratinib
Add to CompareAdded to Compare

Download Files:

Fedratinib

SKU T1995-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 72 CAD through 1,053 CAD

Products Details

Product Description

– Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.

Web ID

– T1995

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H36N6O3S

Citations

– 1. Qian Y, Arellano G, Ifergan I, et al. ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis. Cell Reports. 2021, 36(8): 109602. 2. Ge H, Wang C, Tian C, et al. Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms. Biomedicine & Pharmacotherapy. 2022, 156: 113884 3. Zeng F, Chen H, Chen L, et al An Autocrine Circuit of IL-33 in Keratinocytes is Involved in the Progression of Psoriasis. Journal of Investigative Dermatology. 2020 4. Si H, Wang J, He R, et al. Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor. Frontiers in oncology. 2021, 11: 807200-807200. 5. Qin R, Wang T, He W, et al.Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL.Cell Communication and Signaling.2023, 21(1): 27.

References

– Wernig G, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20.

CAS Number

– 936091-26-8

Molecular Weight

– C27H36N6O3S

Compound Purity

– 0.9941

SMILES

– Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C

Target

– mTOR

Pathway

– JAK/STAT signaling|||Chromatin/Epigenetic|||Stem Cells|||Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Mephenesin
Mephenesin Price range: 53 CAD through 173 CAD
1 g10 g5 g

1000 in stock

Select options
Phenytoin sodium
Phenytoin sodium Price range: 72 CAD through 85 CAD
1 g1 mL * 10 mM (in DMSO)500 mg

1000 in stock

Select options
Ethamsylate
Ethamsylate 46 CAD
1 mL * 10 mM (in DMSO)50 mg

1000 in stock

Select options
AChE-IN-23
AChE-IN-23 Price range: 66 CAD through 150 CAD
100 mg200 mg50 mg

1000 in stock

Select options
4-Hydroxy-6-methylcoumarin
4-Hydroxy-6-methylcoumarin Price range: 46 CAD through 78 CAD
1 mL * 10 mM (in DMSO)500 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (1 Product)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });