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FCCP
Price range: 54 CAD through 787 CAD
Products Details
Product Description
– FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.
Web ID
– T6834
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C10H5F3N4O
Citations
– 1. Liu H, Sun Y, Xu H, et al. PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes. Genes & Diseases. 2022
2. Liang S, Zhu C, Suo C, et al. Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5. Frontiers in Oncology. 2022, 12: 857968-857968
3. Shi J, Zhang F, Chen L, et al. Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore‐forming toxins to Caenorhabditis elegans. Environmental Microbiology. 2021 Sep;23(9):4896-4907
4. Zheng B X, Long W, Zheng W, et al.Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.Journal of Medicinal Chemistry.2024
5. Jiang Z.SLC25A19 is required for NADH homeostasis and mitochondrial respiration.Free Radical Biology and Medicine.2024
6. Muffels I J J, Rodenburg R, Willemen H L D, et al.Imaging Flow Cytometry reveals divergent mitochondrial phenotypes in mitochondrial disease patients.iScience.2024
7. Muffels I J J, Waterham H R, D’Alessandro G, et al.Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance.Genome Medicine.2025, 17(1): 12.
8. Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axis
References
– Brennan JP, et al. FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation. Cardiovasc Res. 2006 Nov 1;72(2):322-30.
CAS Number
– 370-86-5
Molecular Weight
– C10H5F3N4O
Compound Purity
– 0.995
SMILES
– FC(F)(F)Oc1ccc(NN=C(C#N)C#N)cc1
Pathway
– Metabolism|||Membrane transporter/Ion channel
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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