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Products Details
Product Description
– FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC50 = 47 nM). FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC50: 0.24, 0.45, 0.44 μM). FAK-IN-12 induces apoptosis and cellular senescence[1].
Web ID
– HY-156334
Shipping
– Room temperature
Molecular Formula
– C25H25ClN6O3
References
– [1]Liu Y, et al. Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine cinnamyl derivatives as inhibitors of FAK with potent anti-gastric cancer activities. Bioorg Chem. 2023 Sep 30;141:106895.
Molecular Weight
– 492.96
SMILES
– O=C(C1=CC=CC=C1NC2=C(C=NC(NC3=CC=C(C=C3)/C=C/C(N4CCOCC4)=O)=N2)Cl)NC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FAK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
