Ethyl gallate
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Ethyl gallate

SKU T3729-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 67 CAD through 106 CAD

Products Details

Product Description

– Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB and inhibits hydrogen peroxide signaling, may represent an alternative class of vasopressors for use in septic shock. Also, Ethyl gallate suppresses proliferation and invasion in human breast cancer cells by modulating the PI3K/Akt pathway, which may contribute to inhibiting their downstream targets such as NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9 in breast cancer cells, could be used as potential antioxidants with safe therapeutic application in cancer chemotherapy.

Web ID

– T3729

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C9H10O5

Citations

– 1. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 2. Hu Q, Wang S, Cheng R, et al.Tannins in Phyllanthus emblica L. improves Cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger Immunogenic Cell Death.Phytomedicine.2023: 155219.

References

– Cui H, et al. Oncol Rep. Ethyl gallate suppresses proliferation and invasion in human breast cancer cells via Akt-NF-κB signaling. 2015 Mar;33(3):1284-90.

CAS Number

– 831-61-8

Molecular Weight

– C9H10O5

Compound Purity

– 0.9996

SMILES

– C(OCC)(=O)C1=CC(O)=C(O)C(O)=C1

Pathway

– Cytoskeletal Signaling|||Microbiology/Virology|||NF-κB|||Proteases/Proteasome|||PI3K/Akt/mTOR signaling

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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