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Products Details
Product Description
– Esomeprazole-d3 (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
Web ID
– HY-17021S
Shipping
– Room temperature
Molecular Formula
– C17H15D3N3NaO3S
References
– [1]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.|[2]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.|[3]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 370.42
SMILES
– CC(C(OC)=C(C=N1)C)=C1C[S@](C(N2[Na])=NC(C2=C3)=CC=C3OC([2H])([2H])[2H])=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Proton Pump
Pathway
– Membrane Transporter/Ion Channel;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
