Erlotinib

SKU T0373-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 64 CAD through 115 CAD

Products Details

Product Description

– Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.

Web ID

– T0373

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H23N3O4

Citations

– 1. Liu A D, Zhou J, Bi X Y, et al. Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma. Clinical and Translational Medicine. 2021, 11(3): e337 2. Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021 Oct;17(10):3221-3237. 3. Liu A D, Zhou J, Bi X Y, et al. Aptamer‐SH2 superbinder‐based targeted therapy for pancreatic ductal adenocarcinoma. Clinical and Translational Medicine. 2021 Mar;11(3):e337. doi: 10.1002/ctm2.337. 4. Li W, Iusuf D, Sparidans R W, et al.Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.Pharmacological Research.2023: 106724. 5. Pan Q, Xie Y, Zhang Y, et al.EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses.Nature Communications.2024, 15(1): 652. 6. Liang J, Bi G, Sui Q, et al.Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.Cell Reports.2024, 43(2). 7. Zhang C, Sun Y X, Yi D C, et al.Neoadjuvant sintilimab plus chemotherapy in EGFR-mutant NSCLC: Phase 2 trial interim results (NEOTIDE/CTONG2104).Cell Reports Medicine.2024 8. Abdelaal N, Ragheb M A, Hassaneen H M, et al.Design, in silico studies and biological evaluation of novel chalcones tethered triazolo [3, 4-a] isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer.Scientific Reports.2024, 14(1): 26647.

References

– Chin TM, et al. Reduced Erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment. Clin Cancer Res. 2008 Nov 1;14(21):6867-76.

CAS Number

– 183321-74-6

Molecular Weight

– C22H23N3O4

Compound Purity

– 0.9994

SMILES

– N(C=1C2=C(C=C(OCCOC)C(OCCOC)=C2)N=CN1)C3=CC(C#C)=CC=C3

Target

– Antibacterial|||Antibiotic

Pathway

– Autophagy|||Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

Product type

– Small Compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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