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Product Description
– Ep vinyl quinidine (3-Epiquinine) is an epi-vinyl stereoisomer of Quinidine. Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine can be used for malaria research[1][2][3].
Web ID
– HY-114029
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H24N2O2
References
– [1]Hu B, et al. Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions. J Am Chem Soc. 2018 Oct 24;140(42):13913-13920.|[2]Kehl SJ. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13.|[3]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. Pharmacol Ther. 1983;23(2):179-91.
CAS Number
– 101143-87-7
Molecular Weight
– 324.42
SMILES
– O[C@H]([C@]1([H])[N@@]2C[C@H]([C@@H](CC2)C1)C=C)C3=CC=NC4=C3C=C(OC)C=C4
Clinical Information
– Launched
Research Area
– Infection; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
