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Products Details
Product Description
– Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].
Web ID
– HY-155457
Shipping
– Room temperature
Molecular Formula
– C16H16N4O3S
References
– [1]Cho Y et al. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy. J Med Chem. 2023 Nov 23;66(22):15141-15170.
CAS Number
– 2738583-25-8
Molecular Weight
– 344.39
SMILES
– O=C1C2=CC=CC=C2C(CC3=CC=C(NS(=O)(N)=O)C=C3)=NN1C
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE);STING
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
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