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Endosidin-2
Price range: 75 CAD through 1,840 CAD
Products Details
Product Description
– Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.
Web ID
– T37020
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C15H12FIN2O3
References
– Zhang C, et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. 2016;113(1):E41-E50.
CAS Number
– 1839524-44-5
Molecular Weight
– C15H12FIN2O3
Compound Purity
– 0.9829
SMILES
– COC1=CC(C=NNC(=O)C2=CC=CC(F)=C2)=CC(I)=C1O
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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