EML741
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EML741

SKU T11185-25 mg Category Brand:

2,432 CAD

Only 1000 item(s) left in stock.

Products Details

Product Description

– EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a.

Web ID

– T11185

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C31H49N5O2

References

– Milite, et al. Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. J Med Chem. 2019 Mar 14;62(5):2666-2689.

CAS Number

– 2328074-38-8

Molecular Weight

– C31H49N5O2

SMILES

– N(C=1C=2C(N=C(CN1)C3CCCCC3)=CC(OCCCN4CCCC4)=C(OC)C2)C5CCN(C(C)C)CC5

Target

– Others

Pathway

– Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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