EML4-ALK kinase inhibitor 1

$450$3,800

Products Details

Product Description

– EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM[1].

Web ID

– HY-111752

Storage Temperature

– -20°C (Powder, sealed storage, away from moisture and light)

Shipping

– Blue Ice

Applications

– Cancer-Kinase/protease

Molecular Formula

– C31H48N8O3

References

– [1]Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-1692.

CAS Number

– 1373409-08-5

Molecular Weight

– 580.76

Compound Purity

– 98.49

SMILES

– CO[C@H]1CC[C@H](NC2=C(CC)N=C(C(N)=O)C(NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=N2)CC1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 110 mg/mL (ultrasonic)

Target

– Anaplastic lymphoma kinase (ALK)

Pathway

– Protein Tyrosine Kinase/RTK

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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