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Product Description
– Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II. Elomotecan is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II[1].
Web ID
– HY-13622A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H32ClN3O4
References
– [1]Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250.
CAS Number
– 220998-10-7
Molecular Weight
– 522.04
SMILES
– O=C(OC1)C[C@](O)(CC)C2=C1C(N3CC4=C(CN5CCC(C)CC5)C6=CC(C)=C(Cl)C=C6N=C4C3=C2)=O
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Isoform
– Topo I;Topo II
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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