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EIF2α activator 1
$160 – $1,350
Products Details
Product Description
– EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 1 increases the expression level of eIF2α downstream proteins, ATF and CHOP. EIF2α activator 1 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.00 and 19.3 μM, respectively[1].
Web ID
– HY-147831
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H19F6N3O3
References
– [1]Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N’-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.
CAS Number
– 2851820-52-3
Molecular Weight
– 523.43
Compound Purity
– 98.77
SMILES
– N#CC1=CC(C(F)(F)F)=CC(NC2=C(C(C2=O)=O)N[C@@H]3CC[C@@H](OC4=CC=C(C=C4)C(F)(F)F)CC3)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Eukaryotic Initiation Factor (eIF)
Isoform
– eIF2
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
