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Products Details
Product Description
– EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].
Web ID
– HY-146136
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H22N4O3S
References
– [1]Xiao Z, et al. Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115669.
CAS Number
– 2477726-83-1
Molecular Weight
– 434.51
SMILES
– C=CC(NC1=CC=CC(OC2=C(CSCC3)C3=NC(NC4=CC=C(OC)C=C4)=N2)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
