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Products Details
Product Description
– EGFR-IN-51 (Compound 6) is a potent EGFR inhibitor with IC50 values of 0.493, 102.60 and 461.63 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-51 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
Web ID
– HY-146471
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H15N3O2S
References
– [1]Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.
CAS Number
– 2418549-32-1
Molecular Weight
– 373.43
SMILES
– S=C(NC1=C2C=CC=CC2=NC3=C1C=CC=C3)NC4=CC=C5OCOC5=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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