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Products Details
Product Description
– EGFR-IN-47 is a potent and orally active EGFRL858R/T790M/C797S inhibitor with an IC50 of 0.01 µM. EGFR-IN-47 induces cell cycle attest and cell apoptosis. EGFR-IN-47 has the potential for the research of NSCLC[1].
Web ID
– HY-143337
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H35N7
References
– [1]Wang C, et al. Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment. Eur J Med Chem. 2022; 237:114381.
Molecular Weight
– 481.64
SMILES
– NCC(N(C1=N2)C3CCCC3)=CC1=CN=C2NC4=CC=C(N5CCN(CC5)C)C(C6=CC=CC=C6)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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